FeraSpinRisananoparticulatesuperparamagneticironoxidecontrastagentspecificallyformulatedforpre-clinicalmagneticresonanceimaging(MRI).
ItisacontrastagentofhighrelaxivityenhancingthecontrastinT2-andT2*-weightedMRIduetoashorteningofthespin-spinrelaxationtime(T2).
Uponintravenousinjection,FeraSpinRisrapidlytakenupbytheKupffercells(macrophagesoftheliver)resultinginashortbloodhalf-lifeofafewminutes.FeraSpinRaccumulatesparticularlyintheliverandspleenandisdegradedwithitsironbeingtransferredintothephysiologicalironstores.
FeraSpinRisindicatedforuseinMRIofsmallanimals,forexamplemice,tofacilitatethevisualizationoftheliverandspleen.
Examplesincludeimagingoflivertumorsandmetastases.SPIOnanoparticleslikeFeraSpinRcanalsobeusefulfordetectionofbonemarrowmetastases.