当前位置 : Millipore >>> Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL
Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL
  • Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

Millipore/MAB5520 | Anti-NG2 Chondroitin Sulfate Proteoglycan Antibody, clone 7.1/MAB5520/100 µL

价格: ¥3816.00 市场价: 6360.00

货号: MAB5520
品牌: Millipore
规格
数量
库存(0)
特别 提示
代购产品:无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
资深产品顾问
咨询顾问

全国免费服务热线

4000-520-616


  • 自营商城 一站式服务
  • 厂家直采 剔除溢价
  • 品质甄选 正品保证
  • 严控流程 只做188精品
  • 极速物流 如约送货
  • 详情
  • 使用说明
  • 常见问题
    • Description
      CatalogueNumberMAB5520
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1
      AlternateNames
      • NG2
      ProductInformation
      FormatAscites
      PresentationAscitesfluid.Liquid.Containsnopreservative.
      StorageandShippingInformation
      StorageConditionsMaintainat-20°Cinundilutedaliquotsforupto12monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.
      Applications
      ApplicationAnti-NG2ChondroitinSulfateProteoglycanAntibody,clone7.1isanantibodyagainstNG2ChondroitinSulfateProteoglycanforuseinFC&WB.
      KeyApplications
      • FlowCytometry
      • WesternBlotting
      ApplicationNotesWesternblot

      Flowcytometry

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHumanbonemarrowstromalcellline,SV40transformed.
      Clone7.1
      HostMouse
      SpecificityNG2(chondroitinsulfateproteoglycan),humanwhichisthehomologueoftheratNG2molecule.Theantibodyreactswitha220-240kDsurfaceproteinwhoseN-terminalsequenceisidenticaltotheratNG2chondrotinsulfateproteoglycanmolecule.

      MAB5520reactswithonlyneoplasticleukocyteswithspecificassociationwithchromosome11q23translocationsinvolvingtheMLLgene.Ithasaveryhighspecificityfort(4;11)ort(11;19)translocations.Theantibodyshowsnoreactivitywithnormalmarrowhematopoieticcells,peripheralblldleukocytes,redbloodcellsorplatelets.LeukemiccellslinesKG1,KG1a,HRL,Jurkat,K562,Raji,HL-60,U937,Daudi,Nalm6andCEMarenegative.HoweverMAB5520doesreactwithavarietyofcelllinesofnonhematopoieticorigin,includingHeLacells.
      IsotypeIgG1
      SpeciesReactivity
      • Human
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAhumanmelanoma-associatedchondroitinsulfateproteoglycanplaysaroleinstABIlizingcell-substratuminteractionsduringearlyeventsofmelanomacellspreADIngonendothelialbasementmembranes.CSPG4representsanintegralmembranechondroitinsulfateproteoglycanexpressedbyhumanmalignantmelanomacells.
      GeneSymbol
      • CSPG4
      • MSK16
      • MCSP
      • NG2
      • MCSPG
      • MEL-CSPG
      • HMW-MAA
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q6UVK1#Proteoglycanplayingaroleincellproliferationandmigrationwhichstimulatesendothelialcellsmotilityduringmicrovascularmorphogenesis.Mayalsoinhibitneuriteoutgrowthandgrowthconecollapseduringaxonregeneration.Cellsurfacereceptorforcollagenalpha2(VI)whichmayconfercellsabilitytomigrateonthatsubstrate.BindsthroughitsextracellularN-terminusgrowthfactors,extracellularmatrixproteasesmodulatingtheiractivity.MayregulateMPP16-dependentdegradationandinvasionoftypeIcollagenparticipatinginmelanomacellsinvasionproperties.Maymodulatetheplasminogensystembyenhancingplasminogenactivationandinhibitingangiostatin.FunctionsalsoasasignaltransducingproteinbybindingthroughitscytoplasmicC-terminusscaffoldingandsignalingproteins.MaypromoteretractionfiberformationandcellpolarizationthroughRhoGTPaseactivation.Maystimulatealpha-4,beta-1integrin-mediatedadhesionandspreadingbyrecruitingandactivatingasignalingcascadethroughCDC42,ACK1andBCAR1.MayactivateFAKandERK1/ERK2signalingcascades.


      SIZE:2322aminoacids;250497Da

      SUBUNIT:InteractswiththefirstPDZdomainofMPDZ.InteractswithPRKCA.BindsTNC,laminin-1,COL5A1andCOL6A2.InteractswithPLGandangiostatin.BindsFGF2andPDGFA.InteractswithGRIP1,GRIP2andGRIA2.FormsaternarycomplexwithGRIP1andGRIA2(Bysimilarity).InteractswithLGALS3andtheintegrincomposedofITGB1andITGA3.InteractswithITGA4throughitschondroitinsulfateglycosaminoglycan.InteractswithBCAR1,CDC42andACK1.InteractswithMMP16.

      SUBCELLULARLOCATION:Apicalcellmembrane;Single-passtypeImembraneprotein(Bysimilarity).Cellprojection,lamellipodium(Bysimilarity).Note=LocalizedattheapicalplasmamembraneitrelocalizestothelamellipodiaofastrocytomauponphosphorylationbyPRKCA.Localizestotheretractionfibers.Localizestotheplasmamembraneofoligodendrocytes(Bysimilarity).

      TISSUESPECIFICITY:Detectedonlyinmalignantmelanomacells.



      PTM:N-glycosylated(Bysimilarity).&O-glycosylated;containsglycosaminoglycanchondroitinsulfatewhicharerequiredforproperlocalizationandfunctioninstressfiberformation(Bysimilarity).InvolvedininteractionwithMMP16andITGA4.&PhosphorylationbyPRKCAregulatesitssubcellularlocationandfunctionincellmotility(Bysimilarity).


      SIMILARITY:SwissProt:Q6UVK1##Contains15CSPG(NG2)repeats.&Contains2lamininG-likedomains.

      MISCELLANEOUS:ValuableMarkerforseveralincompletelydifferentiatedprecursorcells.
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    蚂蚁淘生物188,秉承蚂蚁淘一贯的严谨态度,由蚂蚁淘公司专业人员负责品控、采购、物流、销售、售后,保障正品优质。以“快速好省,为科研提供好产品、好价格”为理念,直接链接原厂家,从全国各地原制造商严格挑选188款科研精品,剔除品牌溢价,188生物新电商,把好的产品带给科研!  力求给你最优质的商品。
  • Q:生物188产品正品保障吗?
    A:生物188质量把控人员具有十年的从业经验,在业界享有良好的口碑;自营商城,直接从厂家采购, 自己的团队负责国际物流和清关,中间没有第三方,所有流程严格把控,100%保证正品,假一罚十。

    Q:下单后可以修改订单吗?
    A:下单后的商品付款之前可以修改;订单付款成功,需要联系我们客服进行修改;客服电话:4000-520-616

    Q:可以开发票吗?
    A:本网站所售商品都是正规清关,均开具16%正规发票,发票金额含配送费金额,另有说明的除外。

    Q:商品几天可以发货?
    A:生物188商品,全部现货销售,付款后即可发货,一般一周内送达!

    Q:如何联系商家?
    A:有任何问题够可以电话咨询我们,全国24小时免费服务热线:4000-520-616 或联系我们的在线客服QQ:1570468124

    Q:收到的商品少了/发错了怎么办?
    A:同个订单购买多个商品可能会分为一个以上包裹发出,可能不会同时送达,建议查看订单详情是否是 部分发货状态;如未收到,可联系在线客服或者致电4000-520-616。

    Q:退换货/维修需要多长时间?
    A:一般情况下,退货处理周期为客户收到产品一个月内(以快递公司显示签收时间为准),包装规格、 数量、品种不符,外观毁损、短缺或缺陷,请在收到货24小时内申请退换货;特殊商品以合同条款为准。

何为188

极简而严谨,我们仅销售188款生物医学科研用品,款款都是爆款;因为少所以聚焦,聚焦甄选每一款产品,聚焦服务每一位客户!

关注我们 :

点击QQ联系我们
生物188微信

关注188微信公众号

获取最新优惠活动通知
  • 品质甄选,正品保证

  • 自营电商,厂家直采

  • 极简主义,188精品