NormalhumanlungfibroblastsinFGM™-2BulletKit™(seenunderlightmicroscopy)
ProductOverview:
Lonza"sHumanLungFibroblastsareisolatedfromadultlungtissue.Diseasedfibroblasts include lungfibroblastsisolatedfromadultlungtissueofasthma,COPDandcysticfibrosispatients.Somematcheddonorsetsoflungfibroblasts,bronchialsmoothmusclecells,bronchialepithelialcellsmaybeavailable.ContactCustomerServiceorScientificSupportformoreinformation. | | Interestedtolearnmore? Requestinfoorquote |
MostClonetics™PrimaryCellsarealsoavailableas proliferatingcells ineitherflasksorplates,oraspelletsinRNALater®.
Lungfibroblasts playaroleinairwayinflammationandairwayremodeling.Theycanbeatargetforasthmamedicationsinpharmaceutical development. Themostabundantcelltypeinlunginterstitiumisfibroblasts.Theyresembleordinaryfibroblastsbuthavesomedistinguishingfeatures,forexample,theyhavelongbranchingprocessesandgapjunctions.TheirprinciplefunctionisproductionoftypeIIIcollagen,elastin,andproteoglycansoftheextracellularmatrixofthealveolarsepta.Pulmonaryfibroblasts(PF)playanimportantroleintherepairandremodelingprocessesfollowinginjury.Thecontrolledaccumulationoffibroblaststositesofinflammationiscrucialtoeffectivetissuerepairafterinjury.Eitherinadequateorexcessiveaccumulationoffibroblastscouldresultinabnormaltissuefunction.Forexample,theexcessproliferationoffibroblastscontributestotheadventitialthickeningobservedduringthedevelopmentofhypoxia-inducedpulmonaryhypertension.Importantresearchapplicationsincludpulmonarydisease,i.e.COPD,asthma,CF,TB,cancer.
CryopreservedClonetics™NormalHumanLungFibroblastscellsareguaranteedthrough15populationdoublings, theyare testedfornegativevonWillebrandFactorExpression/FactorVIII,cytokeratins18and19,andalpha smoothmuscleactin Allcells testnegativeformycoplasma,bacteria,yeast,andfungi.HIV-1,hepatitisBandhepatitisCarenotdetectedforalldonorsand/orcelllots.ACertificateofAnalysisisprovidedforeachcelllotpurchased.
RecommendedMedium:FGM™-2BulletKit™
RecommendedSubculturingReagents: ReagentPackTM SubcultureReagents
WhitePapers
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Registertodownload | | - DifferentialgeneexpressionbetweennormalanddiseasedlungfibroblastsfromAsthmaandCOPDdonors
- Morewhitepapersavailable
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New!PurchaseourLungFibroblastCellCultureKit(catalogno.CC-2512B)andgetadiscountedpriceoncellsandmedia.Thekit consistsofacryopreservedampuleoflungfibroblastcells(catalogno.CC-2512)andFGM™-2BulletKit™GrowthMedia(catalogno.CC-3132)