Description:Antiviral;activeagainstZika,WestNileanddengueviruses
ChemicalName:(2S,4R,6E,8S)-8-[(2S,2'R,4'S,5R,5'S,7R,7'R,8R,9S,9'S,10'R)-9-Hydroxy-2,4',8,10'-tetramethyl-2'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-9'-[[(2S,5S,6R)-tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl]oxy][2,7'-bi-1,6-dioxaspiro[4.5]dec]-7-yl]-2,4,6-trimethyl-5-oxo-6-nonenoicacidsodiumsalt
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antiviral.InhibitsZikavirusentryinarangeofcelltypesincludingprimaryplacentalfibroblastcells,HUVECsandUtMECs(IC50valuesare0.1,0.4and0.97μMinU2OS,HBMECsandJeg-3cellsrespectively).AlsoinhibitscellularuptakeofWestNile,dengue,sindbisandchikungunyaviruses.
TechnicalData
| M.Wt | 889.1 |
| Formula | C47H77NaO14 |
| Storage | Storeat-20°C |
| CASNumber | 65101-87-3 |
| PubChemID | 46930988 |
| InChIKey | XMAIRYYXDCNFKP-DYTQFKGPSA-M |
| Smiles | [H][C@]1([C@]2(O[C@@](CO)([C@@H](C[C@@H]2C)C)O)[H])C[C@@H]([C@@]3(O[C@](C[C@@H]([C@H]3C)O[C@@]4(CC[C@@H]([C@H](O4)C)OC)[H])([C@@]5(CC[C@@]6(O5)C[C@@H]([C@H]([C@](O6)([C@H](/C=C(C([C@@H](C[C@@H](C(O[Na])=O)C)C)=O)C)C)[H])C)O)C)[H])O1)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 88.91 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight889.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.12mL | 5.62mL | 11.25mL |
| 5mM | 0.22mL | 1.12mL | 2.25mL |
| 10mM | 0.11mL | 0.56mL | 1.12mL |
| 50mM | 0.02mL | 0.11mL | 0.22mL |
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