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IRE-1RNaseinhibitor(IC50=1.23μM).InhibitsIRE-1/XBP1pathway.Cellpermeable.Inhibitsgrowthofhumanchroniclymphocyticleukemia(CLL)cellsinvitroandpromotesCLLregressioninamousemodel.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight303.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Tangetal(2014)InhibitionofERstress-associatedIRE-1/XBP-1pathwayreducesleukemiccellsurvival.J.Clin.Invest.1242585PMID:24812669
Keywords:BI09,supplier,BI09,IRE,inhibitors,inhibits,cell,permeable,in,vivo,active,RNAse,endonuclease,IRE1,IRE1,IRE1,TocrisBioscience
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