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Tocris/GW 3965 hydrochloride/2474/10/10 mg
  • Tocris/GW 3965 hydrochloride/2474/10/10 mg

Tocris/GW 3965 hydrochloride/2474/10/10 mg

价格: ¥2988.00 市场价: 4980.00

货号: 2474/10
品牌: Tocris
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    • Description:OrallyactiveliverXreceptor(LXR)agoNIST
      ChemicalName:3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneaceticacidhydrochloride
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Selective,orallyactivenon-steroidalagonistfortheliverXreceptor(LXR).Incell-basedreportergeneassays,actsasafullagonistofhLXRαandhLXRβ(EC50valuesare190and30nMrespectively).ReducesangiotensinII-mediatedincreasesinbloodpressure;up-regulatesABCA1geneexpressionandraisescirculatingHDLlevels.Displayspotentantiatherogenicactivityinmousemodelsofatherosclerosis.

      LicensingInformation

      SoldforresearchpurposesunderagreementfromGlaxoSmithKline

      CompoundLibraries

      GW3965hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

      TechnicalData

      M.Wt618.51
      FormulaC33H31NO3ClF3.HCl
      StorageDesiccateatRT
      Purity≥98%(HPLC)
      CASNumber405911-17-3
      PubChemID16078973
      InChIKeyNMPUWJFHNOUNQU-UHFFFAOYSA-N
      SmilesCl.OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C2=CC=CC=C2)CC2=C(Cl)C(=CC=C2)C(F)(F)F)=C1

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO61.85100
      ethanol12.3720

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight618.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM1.62mL8.08mL16.17mL
      5mM0.32mL1.62mL3.23mL
      10mM0.16mL0.81mL1.62mL
      50mM0.03mL0.16mL0.32mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

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