Description: Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
Chemical Name: 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
Purity: ≥97% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).
Licensing Information
Sold under license from the NIH, US patent 60/312,674
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Technical Data
M. Wt
286.41
Formula
C19H26O2
Storage
Store at -20°C
Purity
≥97% (HPLC)
CAS Number
536697-79-7
PubChem ID
40469923
InChI Key
ICHJMVMWPKLUKT-JKSUJKDBSA-N
Smiles
COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
28.64
100
ethanol
28.64
100
Preparing Stock Solutions
The following data is based on the product molecular weight 286.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.49 mL
17.46 mL
34.91 mL
5 mM
0.7 mL
3.49 mL
6.98 mL
10 mM
0.35 mL
1.75 mL
3.49 mL
50 mM
0.07 mL
0.35 mL
0.7 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Offertáleret al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780
Moet al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Hoi and Hiley
(2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907
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