当前位置 : Millipore >>> Millipore/14-173M | MAP Kinase 2/Erk2 Protein, active, mouse, 250 µg/14-173M/250 µgAlso available in 10 μg size (c
Millipore/14-173M | MAP Kinase 2/Erk2 Protein, active, mouse, 250 µg/14-173M/250 µgAlso available in 10 μg size (c
  • Millipore/14-173M | MAP Kinase 2/Erk2 Protein, active, mouse, 250 µg/14-173M/250 µgAlso available in 10 μg size (c

Millipore/14-173M | MAP Kinase 2/Erk2 Protein, active, mouse, 250 µg/14-173M/250 µgAlso available in 10 μg size (c

价格: ¥30516.00 市场价: 50860.00

货号: 14-173M
品牌: Millipore
规格
数量
库存(0)
特别 提示
代购产品:无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
资深产品顾问
咨询顾问

全国免费服务热线

4000-520-616


  • 自营商城 一站式服务
  • 厂家直采 剔除溢价
  • 品质甄选 正品保证
  • 严控流程 只做188精品
  • 极速物流 如约送货
  • 详情
  • 使用说明
  • 常见问题
    • Description
      CatalogueNumber14-173M
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionMAPKinase2/Erk2Protein,active,mouse,250µg
      OverviewN-terminalGST-tagged,recombinantMAPKinase2,expressedinE.colicells;activatedusingMEK1(Catalog#14-429).
      ProductInformation
      Presentation50mMTris-HCl,pH7.5,150mMNaCl,0.1mMEGTA,0.03%Brij-35,50%glycerol,1mMbenzamidine,0.2mMPMSF,0.1%2-mercaptoethanol.
      StorageandShippingInformation
      StorageConditionsStoreinundilutedaliquotsat-20°Cforuptooneyearfromthedateofreceipt.Avoidrepeatedefreeze-thawcycles.
      Applications
      ApplicationActive,N-terminalGST-tagged,recombinantMAPKinase2,expressedinE.colicells,activatedusingMEK1.ForuseinKinaseAssays.
      KeyApplications
      • KinaseAssay
      BIOLOGicalInformation
      Sourcerecombinant,mouse,full-lengthMAPKinase2
      SpecificActivityForSpecificActivitydata,refertotheCertificateofAnalysisforindividuallotsofthisenzyme.
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
      GeneSymbol
      • MAPK1
      • p40
      • PRKM2
      • MAPK2
      • PRKM1
      • p42-MAPK
      • p38
      • p41
      • ERK
      • ERK-2
      • ERT1
      • P42MAPK
      • p41mapk
      • ERK2
      ProteinTargetMAPK2
      PurificationMethodGlutathioneagarose;Ni2+/NTAagarose
      TargetSub-FamilyCMGC
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P63085#Serine/threoninekinasewhichactsasanessentialcomponentoftheMAPkinasesignaltransductionpathway.MAPK1/ERK2andMAPK3/ERK1arethe2MAPKswhichplayanimportantroleintheMAPK/ERKcascade.TheyparticipatealsoinasignalingcascadeinitiatedbyactivatedKITandKITLG/SCF.Dependingonthecellularcontext,theMAPK/ERKcascademediatesdiversebiologicalfunctionssuchascellgrowth,adhesion,survivalanddifferentiationthroughtheregulationoftranscription,translation,cytoskeletalrearrangements.ThetheMAPK/ERKcascadeplaysalsoaroleininitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactors.About160substrateshavealreadybeendiscoveredforERKs.Manyofthesesubstratesarelocalizedinthenucleus,andseemtoparticipateintheregulationoftranscriptionuponstimulation.However,othersubstratesarefoundinthecytosolaswellasinothercellularorganelles,andthoseareresponsIBLeforprocessessuchastranslation,mitosisandapoptosis.Moreover,theMAPK/ERKcascadeisalsoinvolvedintheregulationoftheendosomaldynamics,includinglysosomeprocessingandendosomecyclingthroughtheperinuclearrecyclingcompartment(PNRC);aswellasinthefragmentationoftheGolgiapparatusduringmitosis.
      COFACTOR:Magnesium(Bysimilarity).
      DOMAIN:TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
      MolecularWeight67.8kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
    售后保障
    蚂蚁淘生物188,秉承蚂蚁淘一贯的严谨态度,由蚂蚁淘公司专业人员负责品控、采购、物流、销售、售后,保障正品优质。以“快速好省,为科研提供好产品、好价格”为理念,直接链接原厂家,从全国各地原制造商严格挑选188款科研精品,剔除品牌溢价,188生物新电商,把好的产品带给科研!  力求给你最优质的商品。
  • Q:生物188产品正品保障吗?
    A:生物188质量把控人员具有十年的从业经验,在业界享有良好的口碑;自营商城,直接从厂家采购, 自己的团队负责国际物流和清关,中间没有第三方,所有流程严格把控,100%保证正品,假一罚十。

    Q:下单后可以修改订单吗?
    A:下单后的商品付款之前可以修改;订单付款成功,需要联系我们客服进行修改;客服电话:4000-520-616

    Q:可以开发票吗?
    A:本网站所售商品都是正规清关,均开具16%正规发票,发票金额含配送费金额,另有说明的除外。

    Q:商品几天可以发货?
    A:生物188商品,全部现货销售,付款后即可发货,一般一周内送达!

    Q:如何联系商家?
    A:有任何问题够可以电话咨询我们,全国24小时免费服务热线:4000-520-616 或联系我们的在线客服QQ:1570468124

    Q:收到的商品少了/发错了怎么办?
    A:同个订单购买多个商品可能会分为一个以上包裹发出,可能不会同时送达,建议查看订单详情是否是 部分发货状态;如未收到,可联系在线客服或者致电4000-520-616。

    Q:退换货/维修需要多长时间?
    A:一般情况下,退货处理周期为客户收到产品一个月内(以快递公司显示签收时间为准),包装规格、 数量、品种不符,外观毁损、短缺或缺陷,请在收到货24小时内申请退换货;特殊商品以合同条款为准。

何为188

极简而严谨,我们仅销售188款生物医学科研用品,款款都是爆款;因为少所以聚焦,聚焦甄选每一款产品,聚焦服务每一位客户!

关注我们 :

点击QQ联系我们
生物188微信

关注188微信公众号

获取最新优惠活动通知