AdditionalProductInformation:
Description:
Tetanustoxoidisaninactivatedformoftetanustoxin.TetanustoxinisanexotoxinproducedbyClostridiumtetaniandistheagentresponsIBLefor"lockjaw".Tetanustoxinbindstopresynapticmembranesandisinternalizedbynerves.Thetoxinisthentransportedtothecentralnervoussystemthroughretrogradeaxonaltransportwithintheneuron.IntheCNS,thetoxinblocksneurotransmitterreleaseleADIngtothemusclespasmscharacteristicoftetanus.
MolecularWeight:150kD
Structure:Twosubunits,oneheavychainof100kDandalightchainof50kDjoinedbyadisulfidebond.
Storage:Storeat2-8oC. Mixwelljustbeforeuse.
Activity:MaximumTcellstimulationobservedat1ug/mL.
Note:Thispreparationincludesalum.Itissuitableforinvitrostimulationofimmunecellsbutmaynotbesuitableforotheruses.
References:AlanW.Bernheimer,ed.PerspectivesinToxinology,c.1977Wiley,NewYork.
FORRESEARCHUSEONLY.NOTFORDIAGNOSTICORTHERAPEUTICUSE.