NiraWaveCisanear-infrared(NIR)fluorescencecontrastagentwithhighproteinbindingaffinityspecificallyformulatedforpreclinicalopticalimaging.
Itshowsabsorptionandemission(fluorescence)intheNIRspectralrangeallowinganincreasedtissuepenetration.
Uponintravenousinjection,NiraWaveCrapidlybindstoplasmaproteinsandisexcretedunchangedbytheliver.Theplasmaclearanceisbiphasicwithaninitialhalf-lifeof3–4minutesandasecondaryhalf-lifeofmorethan1hour.
NiraWaveCisindicatedforuseinopticalimagingofsmallanimals,forexamplemice,tofacilitatethevisualizationofthevasculature.
Examplesincludefluorescenceangiography.