Vectofusin-1isanon-toxichistidin-richamphipathicpeptidewhichexertsasviraltransductionenhancer.Unlikerecombinantfibronectin,itdoesnothavetobeprecoatedoncellculturesurfaces,thusstreamliningthetransductionprocess.
Genetransferintos
USPensioncellssuchasTcellsorhematopoieticstemcellsusingretroviralvectorshasseveraltherapeuticapplicationsrangingfrommonogenicdiseases,infectiousdiseases,andcancer.Viraltransductionofsuspensioncellsusingretroviralvectorsisofteninefficientandrequirestheuseoftransductionenhancers.Vectofusin-1isafullysyntheticnon-toxiccationicamphipathicpeptidewithviraltransductionenhancingcapacity,enablinghighertransductionlevelswithlowamountsofretroviralvector.Vectofusin-1promotestheentryofseveralretroviralpseudo-typesintotargetcellswhenaddedtotheculturemedium.