Regulatorystatus:Forresearchuseandexvivocellprocessingonly
AvailABIlity:worldwide(1)
Capacity:forstimulationof1×109cells
Content:4mgOverview
The
MACSGMPAspergillusfumigatusLysateconsistsofdisrupted
Aspergillusfumigatusmycelfromthe
ATCCstrain46645.Ithasbeendevelopedforefficient
invitrostimulationandsubsequentisolationof
A.
fumigatus-specificCD4
+andCD8
+Tcells.
Disclaimer
MACSGMPProductsareforresearchuseandexvivocellcultureprocessingonly,andarenotintendedforhumaninvivoapplications.ForregulatorystatusintheUSA,pleasecontactyourlocalrepresentative.
Details
Backgroundinformation
A.fumigatusisoneofthemostubiquitousoftheairbornefungi.Humansandanimalsconstantlyinhalenumeroussporesofthisfungus.A.fumigatushasbecomethemostprevalentairbornefungalpathogen,causingsevereandusuallyfatalinvasiveinfectionsinimmunocompromisedhostsindevelopedcountries.Anincreaseininvasiveaspergillosis(IA)hasbeenobserved.1,2
Applications
The
invitrostimulationof
A.
fumigatus-specificCD4
+andCD8
+TcellswithMACSGMP
AspergillusfumigatusLysateleadstotheupregulationofactivation
Markers,suchasCD137.ThepresenceofCD137onthecellsurfacethenpermitstheenrichmentof
A.
fumigatus-specificeffector/memoryTcellswiththeuseoftheCliniMACSCD137ProductLine.
AdoptivetransferofA.fumigatus-specificTcellsmaybeaneffectivetoolforthetreatmentofpost-engraftmentinvasiveaspergillosis(IA)inhematopoieticstemcelltransplant(HSCT)recipients.
Qualitystatement
MACSGMPProductsaremanufacturedandtestedunderaqualitymanagementsystem(ISO13485)andareincompliancewithrelevantGMPguidelines.Theyaredesignedfollowingtherecommendationsof
USP<1043>onancillarymaterials.