Regulatorystatus:Forresearchuseandexvivocellprocessingonly
AvailABIlity:worldwide(1)
Source:E.coli
Content:25µgOverview
Interleukin2(IL-2),apotentlymphoidcellgrowthfactor,playsanimportantroleinboththeactivationandmaintenanceofimmuneresponsesandinlymphocytedevelopment.IL-2promotes,forinstance,proliferationanddifferentiationofTcells,NKcells,andBcells.
MACSGMPRecombinantHumanIL-2isdesignedfor
exvivocellcultureprocessing.Noanimal-orhuman-derivedmaterialswereusedformanufactureofthisproduct.Theproductislyophilizedwithoutcarrierproteinorpreservatives.
Disclaimer
MACSGMPProductsareforresearchuseandexvivocellcultureprocessingonly,andarenotintendedforhumaninvivoapplications.ForregulatorystatusintheUSA,pleasecontactyourlocalrepresentative.
Details
Backgroundinformation
IL-2isatypicalfourα-helixbundlecytokineandisproducedbyactivatedTcells,especiallytheCD4+Thelpercellpopulation.IL-2signalsthroughareceptorcomplexconsistingofIL-2receptorα-chain(CD25),β-chain,andcommonγ-chain.
Applications
MACSGMPRecombinantHumanIL-2canbeusedforavarietyofapplications,includingtheexvivoactivationandexpansionofTcells,e.g.,antigen-specificcytotoxicTlymphocytes2,3orregulatoryTcells4ortheexvivostimulationofNKcells5,6.
ThespecificactivityisdeterminedbyproliferationassayaccordingtoGearingandBird
1usingCTLL-2cells.Theproliferationassaywascalibratedwiththe2ndinternationalstandardforhumanIL-2(
NIBSCcode86/500)providedbytheNationalInstituteforBiologicalStandardsandControl.
Specificactivity:≥1×106IU/mg
Qualitystatement
MACSGMPProductsaremanufacturedandtestedunderaqualitymanagementsystem(ISO13485)andareincompliancewithrelevantGMPguidelines.Theyaredesignedfollowingtherecommendationsof
USP<1043>onancillarymaterials.