Regulatorystatus:Forresearchuseandexvivocellprocessingonly
AvailABIlity:worldwide(1)
Source:E.coli
Content:25µgOverview
Fibroblastgrowthfactor2(FGF-2),alsotermedbasicFGF,belongstothefamilyofheparin-bindinggrowthfactors.FGF-2functionsasawide-spectrummitogenic,angiogenic,andneurotrophicfactorandstimulatestheproliferationofawidevarietyofcellsincludingmesenchymal,neuroectodermal,andendothelialcells.
MACSGMPRecombinantHumanFGF-2isdesignedfor
exvivocellcultureprocessing.Noanimal-orhuman-derivedmaterialswereusedforthemanufactureofthisproduct.Theproductislyophilizedwithoutcarrierproteinorpreservatives.
Disclaimer
MACSGMPProductsareforresearchuseandexvivocellcultureprocessingonly,andarenotintendedforhumaninvivoapplications.ForregulatorystatusintheUSA,pleasecontactyourlocalrepresentative.
Details
Applications
MACSGMPRecombinantHumanFGF-2canbeusedforavarietyofapplications,includingthecultureofundifferentiatedhumanembryonicstemcells2,3ortheexpansionofmesenchymalstromalcells4,5.
ThespecificactivityisdeterminedbyproliferationassayaccordingtoRobinsonandGaines-Das
1using3T3cells.TheproliferationassaywascalibratedwiththeinternationalstandardforhumanFGF-2(
NIBSCcode90/712)providedbytheNationalInstituteforBiologicalStandardsandControl.
Specificactivity:≥4×105IU/mg
Qualitystatement
MACSGMPProductsaremanufacturedandtestedunderaqualitymanagementsystem(ISO13485)andareincompliancewithrelevantGMPguidelines.Theyaredesignedfollowingtherecommendationsof
USP<1043>onancillarymaterials.