PepTivator®A.fumigatusCatalaseBisapooloflyophilizedpeptides,consistingmainlyof15-mersequenceswith11aminoacidsoverlap,coveringthecompletesequenceofAspergillusfumigatusCatalaseB(UniProtID:Q92405).
Invitrostimulationofantigen-specificTcellswithPepTivatorPeptidePoolscausesthesecretionofeffectorcytokinesandtheup-regulationofactivation
Markers,whichthenallowthedetectionandisolationofantigen-specificTcells.
A.fumigatusisacommonsaprophyticfungus.Itcancauseallergicbronchopulmonaryaspergillosisorcaninducesevereinfectionsoftherespiratorytractinimmunocompromisedindividuals.ItissuggestedthatCD4+Tcellsplayacentralroleinthepreventionandeliminationoftheseinfections.
PepTivatorA.fumigatusCatalaseB–researchgradehasbeenspecificallydevelopedforefficientinvitrostimulationofA.fumigatusAspCatalaseB–specificTcells.Peptidesof15aminoacidsinlengthand11aminoacidsoverlaprepresentanoptimizedsolutionforstimulatingbothCD4+andCD8+Tcellsinvariousapplications,including: