CloneMAR-1detectsthealphasubunitofthemurinehigh-affinityFcreceptorforIgE.Thereceptoriscomposedofonealpha,onebeta,andtwodisulfid-linkedgammasubunits,ofwhichthealphasubunitbindsIgE1.FcεRIαisexpressedonmastandbasophiliccellsandisup-regulatedinthepresenceofIgE2,3.TheFcεRIcomplexplaysanimportantroleintriggeringIgE-mediatedallergicreactions.
TheAnti-FcεRIαpure-functionalgradeantibodyissuitedforfunctionalassays,forexample,blockingofreceptor-ligandbinding.